Projectes de recerca oberts a candidatures
Research projects
During sleep and dreaming the brain internally produces realistic simulations which are thought to play an important role in learning, creativity and memory. The project aims to gain a mechanistic understanding of the circuits through which the brain can internally generate this highly structured cortical neural activity during sleep, how this activity is coordinated between brain regions, and the function it serves in learning, creativity and memory. To answer these questions, we use in vivo brain imaging to probe and manipulate cortical circuits at cellular resolution in in mice during learning and sleep.
The candidate will have access to state-of-the-art in vivo 2-photon calcium imaging, holographic optogenetic and virtual reality approaches to measure and perturb neural circuits in awake behaving and sleeping mice at cellular and subcellular resolution.
Candidates, please contact Dr. Adam Ranson: adam.ranson@uab.cat
In your application please include:
- A CV describing relevant experience and skills. This should include any practical experimental experience and knowledge of data analysis approaches (such as in python or MATLAB).
- An expression of interest letter describing why you are attracted to this position.
- In the case of applications to PhD fellowships, full undergraduate transcripts and a document summarising overall GPA for undergraduate and masters courses. Ideally these should be provided as converted to the Spanish system using the following website.
The project aims to gain a mechanistic understanding of how cannabinoids such as THC and CBD act in the brain—which circuits and cell types are engaged, what molecular programs are recruited, and how these mechanisms relate to behavior. To address these questions, we will combine snRNA-seq, translatomics, and lipidomics with mouse behavioral studies and targeted experimental perturbations.
The candidate will have access to state-of-the-art omics platforms and in vivo mouse behavioral approaches, and will work within a highly collaborative environment with expertise in cannabinoid neuropharmacology, circuit neuroscience, and translational models relevant to CNS disease.
Applicants should have a strong background in neuroscience/neuropharmacology and an interest in how cannabinoids modulate brain circuits and behavior. Experience in at least one of the following is expected: -Omics: snRNA-seq, translatomics, and/or lipidomics; -Circuit methods (e.g., stereotaxic surgery, viral tools) and mouse behavior; -Data analysis in R/Python for high-dimensional datasets.
Candidates, please contact Dr. Emma Puighermanal: emma.puighermanal@uab.cat
Our research is focused on exploring the different microenvironments of human glioma samples, and analyze experimental models in vivo and in vitro, to understand the function of immune cells, especially microglia-macrophages to achieve tumor clearance. The outcome of this project will suggest novel strategies for immunotherapy.
Techniques: Mapping the cellular populations in tissue from biopsies of patients and glioblastoma models in mice by using high-resolution immunohistofluorescence and histocytometry. Use in vivo and in vitro models to study and test immunotherapeutic strategies.
Candidates should have knowledge on advanced microscopy (Confocal Imaging). Previous experience with animal experimentation and particularly, stereotaxic surgery in mouse brain will be highly valued.
Candidates, please contact Dr. Carlos Barcia: carlos.barcia@uab.cat
The project aims to uncover the molecular mechanisms that drive selective neuronal vulnerability in primary mitochondrial disease, focusing on how defects in mitochondrial complex I trigger neurodegeneration. To address this, we will use a Ndufs4-deficient mouse model and combine transcriptional, metabolic, and biochemical profiling with high-resolution imaging, pharmacological interventions, and behavioral analyses to dissect PKR-mediated antiviral responses, lipid droplet dynamics, and their contribution to neuronal death.
The candidate will have access to cutting-edge omics platforms and in vivo mouse behavioral assays, and will be embedded in a highly collaborative research environment.
Applicants should have a strong background in neuroscience, cell biology, or a related field, and a clear interest in the molecular and cellular mechanisms underlying neurodegeneration and mitochondrial disease. Experience in at least one of the following areas is expected: 1) Omics approaches, such as transcriptomics, metabolomics, and/or lipidomics; 2) In vivo mouse work, including disease models, pharmacological interventions, and histological or imaging techniques; 3) Data analysis using R and/or Python, particularly for high-dimensional biological datasets.
Candidates, please contact Dr. Albert Quintana: albert.quintana@uab.cat