Puig2lab

Research at the Puig2 Lab is focused on elucidating the molecular mechanisms underlying the effects of cannabinoids in the brain under both physiological and pathological conditions. One main line of research involves studying the pharmacological effects of cannabinoids (both endocannabinoids and plant-derived) in specific mouse behaviors, particularly memory processes, and their underlying cellular and molecular effects. This research is being conducted in collaboration with Dr. Valjent (CNRS, France), Dr. Marsicano (INSERM, France), Dr. Gertsch (University of Bern, Switzerland), and Dr. Ding (Stanford University, USA).

The second main line of research is related to pathology and focuses on assessing the therapeutic effects of the non-psychoactive cannabinoid cannabidiol (CBD) in primary mitochondrial diseases. This research is being carried out in collaboration with Dr. Quintana (UAB) and Dr. Bellusci (12 de Octubre Hospital).

• Elucidation of the cell type-specific molecular mechanisms underlying the effects of delta9-tetrahydrocannabinol in memory impairment.
• Study of the potential therapeutic effects of cannabidiol in primary mitochondrial diseases.
• Development of proprietary combination drugs for the treatment of primary mitochondrial diseases.

We are interested in investigating the intricate molecular mechanisms governing the effects of cannabinoids on the brain, examining both physiological and pathological contexts. Our primary focus is on understanding the pharmacological effects of cannabinoids, which include both endocannabinoids and plant-derived compounds, by closely scrutinizing mouse behaviors, particularly in the realm of memory processes. Collaborating with esteemed researchers nationally and internationally, we enrich the interdisciplinary nature of our exploration.

Studying the endocannabinoid system contributes to maintaining homeostasis in the body and plays a pivotal role in regulating various physiological processes, including memory, pain, and appetite. Understanding how cannabinoids, both endogenous and exogenous, interact with this intricate system provides insights into fundamental aspects of neurobiology and can have profound implications for medical applications. Marijuana components, such as THC and CBD, exert their effects by interacting with the endocannabinoid system, affecting neurotransmitter release and neuronal activity. Investigating these interactions is essential for unlocking the therapeutic potential of cannabinoids and advancing our comprehension of their impact on brain function and overall health.