Mitochondrial neuropathology

Our research group's strategic objectives revolve around unraveling the intricate relationship between mitochondrial function and neuropathology, aiming to decipher the underlying mechanisms and develop innovative therapeutic strategies. Key objectives include: 

• Elucidating Neuronal Susceptibility to Mitochondrial Dysfunction: Investigating why certain neuronal populations are more prone to mitochondrial dysfunction and how this contributes to neuropathological conditions. 
• Developing Targeted Mitochondrial Manipulation Tools: Innovating novel tools and techniques to selectively manipulate mitochondrial function in specific cell types, facilitating precise interventions for therapeutic purposes. 
• Exploring the Role of Kiss1 Neurons in Reproductive Health: Delving into the involvement of Kiss1 neurons in male and female reproductive health, shedding light on potential therapeutic avenues for reproductive disorders. 
• Understanding Mitochondrial Metabolism in Hypothalamic Function: Examining the impact of mitochondrial metabolism on hypothalamic function, aiming to uncover its significance in regulating various physiological processes 

• Dissecting neuronal susceptibility to mitochondrial dysfunction. 
• Developing novel tools for cell type-specific mitochondrial manipulation. 
• Assessing the contribution of mitochondrial metabolism in hypothalamic function. 
• Parsing the role of Kiss1 neurons in male and female reproductive health 

Our research interests span across various domains of mitochondrial neuropathology, aiming to bridge the gap between fundamental research and clinical applications. We are particularly interested in elucidating the complex interplay between mitochondrial function and neurological disorders, such as Parkinson's disease, Alzheimer's disease, and mitochondrial encephalopathies. Additionally, we are keen on understanding the molecular mechanisms underlying mitochondrial dynamics, fusion, and fission, and their implications in neuronal homeostasis and disease progression.  

Furthermore, we are deeply invested in translational research, striving to develop innovative therapeutic interventions for mitochondrial diseases. This includes the exploration of small molecules, gene therapies, and other targeted approaches to modulate mitochondrial function and mitigate neuropathological outcomes. 

Overall, our research endeavors are driven by a passion for unraveling the mysteries of mitochondrial neuropathology and translating these findings into tangible benefits for patients suffering from neurological disorders.