Neuroinflamación y Estrés Oxidativo

Caracteritzación del rol de citocinas como la interleucina 6 en modelos animals de Alzheimer.

1. Rol de la IL-6 y la trans-señalización de IL-6 en modelos murinos de enfermedades neurodegenerativas y neuroinflamatorias (Ref PID2021-126602OB-I00; Ministerio de Ciencia e Innovación, y FEDER)

• Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome. Glia. 2022 Nov;70(11):2032-2044. doi: 10.1002/glia.24234. Epub 2022 Jun 30.
• Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease. Nat Cardiovasc Res. 2022 Jan;1(1):28-44. doi: 10.1038/s44161-021-00002-8. Epub 2021 Dec 23.
• Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons. Immunity. 2021 Feb 9;54(2):225-234.e6. doi: 10.1016/j.immuni.2020.12.016. Epub 2021 Jan 20.
• A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020 Oct 15;17(1):304. doi: 10.1186/s12974-020-01969-0.
• Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts. J Clin Invest. 2020 Jun 1;130(6):2888-2902. doi: 10.1172/JCI133572.
• Regulation of adipose tissue inflammation by interleukin 6. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2751-2760. doi: 10.1073/pnas.1920004117. Epub 2020 Jan 24.
• Microglial cell-derived interleukin-6 influences behavior and inflammatory response in the brain following traumatic brain injury. Glia. 2020 May;68(5):999-1016. doi: 10.1002/glia.23758. Epub 2019 Dec 4.
• IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease. Brain Behav Immun. 2019 Nov;82:145-159. doi: 10.1016/j.bbi.2019.08.005. Epub 2019 Aug 8.
• Different Responses to a High-Fat Diet in IL-6 Conditional Knockout Mice Driven by Constitutive GFAP-Cre and Synapsin 1-Cre Expression. Neuroendocrinology. 2019;109(2):113-130. doi: 10.1159/000496845. Epub 2019 Jan 13.
• Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 2017 Jan;18(1):74-85. doi: 10.1038/ni.3632. Epub 2016 Nov 28.