Institute of Biotechnology and Biomedicine (IBB)

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Description

The Institute of Biotechnology and Biomedicine "Vicent Villar Palasí" (IBB; formally known as the Institute of Fundamental Biology, IBF) was created in 1970 as an institute belonging to the Universitat Autònoma de Barcelona (UAB) with the main objective of promoting and facilitating basic and fundamental biological research.
 
Today, the institute includes research groups in seven areas of expertise: Bioinformatics, Cell Biology, Structural Biology, Genomics, Immunology, Microbiology and Proteomics. This multidisciplinary character, one of the most relevant characteristics of the IBB, allows for a broad approach to biological problems, both basic and applied.
 
In the year 2000, the focus of research evolved towards the Biotechnology and Biomedicine fields, with the aim of advancing scientific findings into translational results.

Among the over 200 researchers currently working at the IBB, there are lecturers and professors from the UAB, ICREA and other senior researchers, postdoctoral fellows, and students in training, as well as technology services and platforms created within IBB and which now function independently.

Links to the UAB

Institute affiliated to the Universitat Autònoma de Barcelona.

Strategic research areas

Research conducted at the IBB is currently at an interface between biotechnology and biomedicine and consists of a multidisciplinary approach. The main lines of research are:

- Molecular bases of the pathogenesis and resistance to drugs of different pathogens.
- Study of effector and regulatory mechanisms of the immune response in autoimmune process models: endocrine autoimmunity, role of the thymus in the generation of regenerative cells and the generation of immunological tolerance
- Antigen processing and presentation by MHC and lymphocyte recognition.
- Proteomic, interactomic and analysis of protein ligands in natural biological samples. Methodological development and applications of protease inhibitors for cancer and malaria treatments.
- Study of the structure and folding of proteins and their relation with molecular mechanisms causing disorders such as Alzheimer's or Parkinson's disease.
- Contribution to the inflammation and oxidative stress in autoimmune disorders.
- Nutrients with immunomodulative capacities and their applications in preventive medicine.
- Study of the genome instability and its implication in diverse cancer processes and within the evolution of mammals
- Study of the evolution of pathogen recognition in vertebrates, with emphasis on LPS recognition and signaling, using fish macrophage as models
- Evolutionary and functional analysis of the structural variants and changes in gene expression within the human genome.
- Design of new vehicles for gene therapy: Design, biological production and characterisation of nanoparticles, based on multifunctional proteins, for targeted DNA delivery and other nucleic acid therapeutics
- Development of nanovaccines for commercial fish species
- Biomolecular and bioinformatic modeling and simulation of proteins and their interactions in the design of vaccines
- Study of the enzymatic catalysis using Quantum Mechanics and simulations of Molecular Dynamics: reaction mechanisms, calculation of speed constants and isotope kinetic effects, and the design of inhibitors
- Bioinformatic, proteomic and expression analysis of minimal cellular genome(mycoplasma). Applications for the study of pathogenicity and the obtaining of vaccines.
- Stress response mechanisms in yeast and the regulation of phosphorylation-dephosphorylation in proteins.
- Representation, analysis and interpretation of the nucleotide variation and its relation with genomic, phenotypic and environmental variants.

Services of interest to the UAB CEI community

Courses, seminars, work and grants
SCAC (Servei de Cultius Cel·lular, Producció d’Anticossos i Citometría) 
SGB (Servei de Genòmica i Bioinformàtica)
sepBioEs (Servei de Proteòmica i Biologia Estructural)

Contact

Responsible: Dr Salvador Ventura Zamora

Address: UAB University Campus - Bellaterra (08193) Cerdanyola del Vallès

Telephone: 93 581 1233 / 93 581 3582

E-mail: ibb@uab.cat

Website: http://ibb.uab.es