|La Unidad de Medicina convoca una plaza postdoctoral|
Convocatoras y Concursos
El laboratorio del doctor José M. López busca un becario postdoctoral interesado en el estudio del mecanismo de moléculas metabólicas y neurogénicas de una enfermedad.
Postdoctoral Position | Biology, Biochemistry, Neurology
Universitat Autònoma de Barcelona
The laboratory of Dr. José M. López (https://inc.uab.cat/es/investigadors/info/josemanuel-lopez-blanco) at Universitat Autònoma de Barcelona, Department of Biochemistry and Molecular Biology, School of Medicine, is seeking a postdoctoral fellow interested in the study of the molecular mechanisms of a metabolic and neurogenetic disease.
The lab has an open position to study the cellular alterations and the mechanisms responsible for neuronal dysfunction in Lesch-Nyhan Disease (LND), an X-linked disease with characteristic neurobehavioral abnormalities. This disease is caused by mutations in the HPRT1 gene, which encodes the hypoxanthine-guanine phosphoribosyltransferase (HGprt) enzyme. This enzyme is expressed in nearly all cells and plays a well-characterized role in purine biochemistry that involves recycling free bases and maintaining nucleotide pools, important for energy homeostasis, DNA and RNA synthesis, intra- and inter-cellular signally, and other functions. Although the mechanism by which HGprt deficiency leads to the neurobehavioral abnormalities remains unclear, purines have been shown to influence many aspects of neural function and development. Fibroblasts, lymphocytes, and iPSCs obtained from LND patients and normal controls will be used to study the biochemical alterations induced by HPRT1 deficiency. Potential therapies, with different drugs, will be assayed to revert the cellular alterations observed in LND.
The successful applicant should have a recent Ph.D. in Biological Sciences, Biochemistry, or Neuroscience. Prior experience with cell culture, HPLC, and proteomic analysis is recommended. Interested individuals should send a brief cover letter, CV, and references and/or letters of recommendation to Dr. José M. López at email@example.com.
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