Alfredo Miñano Molina
  • Biography
    We are interested in the molecular events that are responsible for the decrease in glutamatergic neurotransmission elicited by amyloid-beta. Particularly in the relationship between oligomer forms of amyloid-beta, alteration in synaptic glutamatergic receptors and early cognitive deficits related to Alzheimer’s disease.
    The goals of my present research are:
    (1) To characterize the molecular mechanisms underlying amyloid-beta oligomers-dependent synaptic depression using molecular and cell biological approaches.
    (2) To analyze the regulation of synaptic proteins in response to synaptic stimuli under amyloid-beta depression conditions using imaging techniques and replacement technology.
    (3) To implement the molecular replacement technology using stereotaxic injections in vivo in a mouse model of Alzheimer Disease.
    (4) To find out new biomarkers related with early diagnostic in Alzheimer’s disease.

    Post-doctoral stay("José Castillejo" Mobility Fellowship) at Nancy Pritzker Lab, Psychiatry & Behavioral Sciences, Stanford University School of Medicine. Palo Alto (California) United States. From March to September, 2012.
    My research at Dr Robert C. Malenka's laboratory was aimed to elucidate the specific molecular events that are responsible for the exocytosis of neurotransmitter receptors. To accomplish this I used imaging techniques (Confocal Microscopy) and molecular and cell biological approaches to examine the activity-dependent modulation of neurotransmitter receptors.
    Pre-doctoral stayat Departamento de Biología Celular, Facultad de Biología. Universidad de Valencia. Valencia (Spain). From April to December 2002.
    My research at Dra Isabel Fariñas’ laboratory was aimed to investigate the neurodegenerative effect of alpha-synuclein protein accumulation in front of several cell death stimuli. To accomplish this I used neuronal primary cultures from wild type and alpha-synuclein-knock out mice and molecular and cell biological approaches.

    Teacher Training Program in European Higher Education Area, (FDES program); Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.2011-2012. Within the framework of European university harmonisation, the Teacher Training Plan of UFI aims to provide UAB lecturers with a variety of tools and resources to help them implement innovation initiatives and to improve the quality of their teaching.
    Ph.D., in Biochemistry and Molecular Biology; UAB, Barcelona, Spain. 2000-2006. Supervisor: José Rodríguez Álvarez. PhD project: “Effects of 17-beta-estradiol on survival and modulation of neuronal plasticity in cultured rat cerebellar granule neurons.”
    Post-graduate Pedagogic Aptitude Certificate, Life Sciences. UAB, Barcelona, Spain. 2000-2001.
    B.Sc, Biochemistry, UAB, Barcelona, Spain. 1995-2000.

    Professor, Faculty of Medicine, Medicine Degree.
    Mentor of the Master’s Degree in Neuroscience.
    Mentor of the PhD Neuroscience Program.
    Advisor at the PhD Neuroscience Program.
    Science outreach communicator.
  • Research groups
  • Cross-talk beetween molecular mechanisms involved in neuronal survival and apoptosis
  • More information
  • Researcher ID C-9863-2011



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