Seminario grupo "Statistical Modeling of Extreme Events and Health Risks" - Servei d'Estadística Aplicada
Título: Radiation dose estimation: the intersection of biology and statistics in biodosimetry
Conferenciante: Dorota Mlynarczyk - Departament de Matemàtiques, UAB
Día y hora: Jueves, 25 de abril de 2024 a las 12:00 a la Sala de seminari (C1/028) del Centre de Recerca Matemàtica (CRM) u online Teams
Lugar: Sala de seminaris (C1/028), Centre de Recerca Matemàtica (CRM), Facultat de Ciències, campus de la UAB.Tambien se puede asistir al seminario online (vía Teams): enlace al seminario online
Duración: 1 hora aproximadamente
Inscripción: La asistencia a este seminario es gratuita. Por motivos de aforo os agradeceríamos que os registrarais: Formulario registro seminario
Abstract:
Biological dosimetry relies on statistical methodologies to estimate radiation doses absorbed by individuals following accidental or therapeutic exposure. Central to this process is the assessment of various biomarkers' frequencies within blood cells, which serve as indicators of radiation-induced damage. Therefore, mathematical modelling in biodosimetry integrates biology, statistics, and advanced computational techniques to provide accurate and timely estimation of radiation dose in case of emergency. Complexity arises from the distinctive characteristics inherent to each biomarker. For instance, levels of gamma-H2AX change over post-radiation time, requiring three-dimensional models to capture dose-time dynamics. Partial body radiation, when only part of human body is exposed to radiation, leads to zero-inflated models. Incorporating these factors into mathematical models enhances the precision and reliability of dose estimation, crucial for optimizing treatment strategies following radiation exposure incidents.
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